Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use
Joint Authors
Kotwal, Anupam
Cutrona, Sarah L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system.
It is classically associated with the simultaneous administration of two serotonergic agents, but it can occur after initiation of a single serotonergic drug or increasing the dose of a serotonergic drug in individuals who are particularly sensitive to serotonin.
We describe a case of serotonin syndrome that occurred after ingestion of higher than prescribed doses of lamotrigine and aripiprazole, in addition to cocaine abuse.
The diagnosis was established based on Hunter toxicity criteria and severity was classified as mild.
The features of this syndrome resolved shortly after discontinuation of the offending agents.
Serotonin syndrome is characterized by mental status changes, autonomic hyperactivity, and neuromuscular abnormalities along a spectrum ranging from mild to severe.
Serotonin syndrome in our patient was most likely caused by the pharmacokinetic and pharmacodynamic interactions between lamotrigine, aripiprazole, and cocaine leading to increased CNS serotonergic activity.
American Psychological Association (APA)
Kotwal, Anupam& Cutrona, Sarah L.. 2015. Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use. Case Reports in Medicine،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058907
Modern Language Association (MLA)
Kotwal, Anupam& Cutrona, Sarah L.. Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use. Case Reports in Medicine No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058907
American Medical Association (AMA)
Kotwal, Anupam& Cutrona, Sarah L.. Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use. Case Reports in Medicine. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058907