Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy

Abstract EN

Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation.

Warfarin-related nephropathy is an increasingly recognized entity, but recent evidencesuggests that dabigatran can cause a WRN-like syndrome.

We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that,despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulationcascade and barrier abnormalities caused by molecular mechanisms.