Sildenafil Induced Acute Interstitial Nephritis
Joint Authors
Burkhart, Ryan
Shah, Nina
Lewin, Matthew
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Acute interstitial nephritis (AIN) is characterized by inflammation of the renal interstitium and usually occurs in a temporal relationship with the medication.
We present a case of an Asian male who had nephrotic range proteinuria and presented with acute kidney injury.
The patient reported an acute change in physical appearance and symptomatology after the ingestion of a single dose of sildenafil.
Renal biopsy was notable for minimal change disease (MCD) with acute and chronic interstitial nephritis.
Renal replacement and glucocorticoid therapy were initiated.
Renal recovery within six weeks permitted discontinuation of dialysis.
AIN superimposed on MCD is a known association of NSAID induced nephropathy.
The temporal association and the absence of any new drugs suggest that the AIN was most likely due to the sildenafil.
NSAIDs are less likely to have caused the AIN given their remote use.
The ease of steroid responsiveness would also suggest another cause as NSAID induced AIN is often steroid resistant.
The MCD was most likely idiopathic given the lack of temporal association with a secondary cause.
As the number of sildenafil prescriptions increases, more cases of AIN may be identified and physician awareness for this potential drug disease association is necessary.
American Psychological Association (APA)
Burkhart, Ryan& Shah, Nina& Lewin, Matthew. 2015. Sildenafil Induced Acute Interstitial Nephritis. Case Reports in Nephrology،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058975
Modern Language Association (MLA)
Burkhart, Ryan…[et al.]. Sildenafil Induced Acute Interstitial Nephritis. Case Reports in Nephrology No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058975
American Medical Association (AMA)
Burkhart, Ryan& Shah, Nina& Lewin, Matthew. Sildenafil Induced Acute Interstitial Nephritis. Case Reports in Nephrology. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058975