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Donor-Derived Myeloid Sarcoma in Two Kidney Transplant Recipients from a Single Donor
Joint Authors
Iskandar, Samy S.
Palanisamy, Amudha
Persad, Paul
Koty, Patrick P.
Douglas, Laurie L.
Stratta, Robert J.
Rogers, Jeffrey
Reeves-Daniel, Amber M.
Orlando, Giuseppe
Farney, Alan C.
Beaty, Michael W.
Pettenati, Mark J.
Grier, David D.
Kaczmorski, Scott A.
Doares, William H.
Gautreaux, Michael D.
Freedman, Barry I.
Powell, Bayard L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report the rare occurrence of donor-derived myeloid sarcoma in two kidney transplant patients who received organs from a single deceased donor.
There was no evidence of preexisting hematologic malignancy in the donor at the time of organ recovery.
Both recipients developed leukemic involvement that appeared to be limited to the transplanted organ.
Fluorescence in situ hybridization (FISH) and molecular genotyping analyses confirmed that the malignant cells were of donor origin in each patient.
Allograft nephrectomy and immediate withdrawal of immunosuppression were performed in both cases; systemic chemotherapy was subsequently administered to one patient.
Both recipients were in remission at least one year following the diagnosis of donor-derived myeloid sarcoma.
These cases suggest that restoration of the immune system after withdrawal of immunosuppressive therapy and allograft nephrectomy may be sufficient to control HLA-mismatched donor-derived myeloid sarcoma without systemic involvement.
American Psychological Association (APA)
Palanisamy, Amudha& Persad, Paul& Koty, Patrick P.& Douglas, Laurie L.& Stratta, Robert J.& Rogers, Jeffrey…[et al.]. 2015. Donor-Derived Myeloid Sarcoma in Two Kidney Transplant Recipients from a Single Donor. Case Reports in Nephrology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058981
Modern Language Association (MLA)
Palanisamy, Amudha…[et al.]. Donor-Derived Myeloid Sarcoma in Two Kidney Transplant Recipients from a Single Donor. Case Reports in Nephrology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1058981
American Medical Association (AMA)
Palanisamy, Amudha& Persad, Paul& Koty, Patrick P.& Douglas, Laurie L.& Stratta, Robert J.& Rogers, Jeffrey…[et al.]. Donor-Derived Myeloid Sarcoma in Two Kidney Transplant Recipients from a Single Donor. Case Reports in Nephrology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058981