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JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings
Joint Authors
Babi, Mohamed-Ali
Pendlebury, William
Braff, Steven
Waheed, Waqar
Source
Case Reports in Neurological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We describe a case with a false-negative PCR-based analysis for JC virus in cerebrospinal fluid (CSF) in a patient with clinical and radiological findings suggestive of progressive multifocal leukoencephalopathy (PML) who was on chronic immunosuppressive therapy for rheumatoid arthritis.
Our patient developed rapidly progressive global decline with clinical and radiographic findings suggestive of PML, but JC virus PCR in CSF was negative.
The patient passed away 3 months from the onset of her neurological symptoms.
Autopsy confirmed the diagnosis of PML with presence of JC-polyoma virus by immunohistochemical staining.
This case highlights the potential of false-negative JC virus PCR in CSF when radiographic and clinical features are suggestive of “possible PML.” We review the plausible causes of potential false-negative CSF results and suggest that when the clinical presentation is suspicious for PML repeat CSF analysis utilizing ultrasensitive PCR assay and subsequent brain biopsy should be considered if CSF remains negative.
Additionally, appropriate exclusion of other neurologic conditions is essential.
American Psychological Association (APA)
Babi, Mohamed-Ali& Pendlebury, William& Braff, Steven& Waheed, Waqar. 2015. JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings. Case Reports in Neurological Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059050
Modern Language Association (MLA)
Babi, Mohamed-Ali…[et al.]. JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings. Case Reports in Neurological Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059050
American Medical Association (AMA)
Babi, Mohamed-Ali& Pendlebury, William& Braff, Steven& Waheed, Waqar. JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings. Case Reports in Neurological Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059050