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A Potential Role for Felbamate in TSC- and NF1-Related Epilepsy: A Case Report and Review of the Literature
Joint Authors
Mishal, Natanya M.
Arkilo, Dimitrios
Tang, Ju
Wang, Sonya G.
Crawford, J. R.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A 15-year-old girl with maternal inheritance of neurofibromatosis type 1 (NF1) and paternal inheritance of tuberous sclerosis complex (TSC) developed intractable epilepsy at age 5.
Her seizures were refractory to adequate doses of four antiepileptic medications until felbamate was initiated at age 7.
She has since remained seizure-free on felbamate monotherapy.
Although felbamate has multiple mechanisms of action, it is thought to have its most potent antiepileptic effects through inhibition of the N-methyl-D-aspartate receptor (NMDAR).
Previous studies have shown that the NMDAR is altered in varying epilepsy syndromes and notably in the cortical tubers found in TSC.
The aim of this paper is to examine how felbamate monotherapy was able to achieve such robust antiepileptic effects in a unique patient and possibly offer a novel therapeutic approach to patients suffering from TSC- and NF-related epilepsy.
American Psychological Association (APA)
Mishal, Natanya M.& Arkilo, Dimitrios& Tang, Ju& Crawford, J. R.& Wang, Sonya G.. 2015. A Potential Role for Felbamate in TSC- and NF1-Related Epilepsy: A Case Report and Review of the Literature. Case Reports in Neurological Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059076
Modern Language Association (MLA)
Mishal, Natanya M.…[et al.]. A Potential Role for Felbamate in TSC- and NF1-Related Epilepsy: A Case Report and Review of the Literature. Case Reports in Neurological Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1059076
American Medical Association (AMA)
Mishal, Natanya M.& Arkilo, Dimitrios& Tang, Ju& Crawford, J. R.& Wang, Sonya G.. A Potential Role for Felbamate in TSC- and NF1-Related Epilepsy: A Case Report and Review of the Literature. Case Reports in Neurological Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059076