A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature
Joint Authors
Pirollo, Linda Maria Azzurra
Salehi, Leila Baghernajad
Sarta, Simona
Cassone, Marco
Capogna, Maria Vittoria
Piccione, Emilio
Novelli, Giuseppe
Pietropolli, Adalgisa
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pentasomy X is a rare chromosomal abnormality probably due to a nondisjunction during the meiosis.
Only four cases prenatally diagnosed were described until now.
Our case is the fifth one prenatally diagnosed at 20 weeks of gestational age in a 39-years-old woman.
She underwent invasive prenatal diagnosis for her advanced maternal age without any other known risk factor.
Amniocentesis performed at 17 weeks showed a female 49, XXXXX karyotype.
The ultrasonographic examination revealed nonspecific signs of a mild early fetal growth retardation and no significant increased nuchal fold.
The fetal autopsy and the X-ray excluded major malformations.
Prenatal diagnosis is often difficult due to the lack of indicative ultrasonographic findings and the rarity of described cases.
The influence of the mother’s age on the occurrence of penta-X syndrome has not been determined.
Considering the lack of correlation between advanced maternal age and increased risk for pentasomy X, as well as the absence of typical echographic signs, evaluation of the inclusion of a noninvasive prenatal test (NIPT) that expands clinical coverage to include the X and Y chromosomes in routine prenatal diagnosis should be considered as well as three-dimensional ultrasound to detect any helpful indicative prognostic signs.
American Psychological Association (APA)
Pirollo, Linda Maria Azzurra& Salehi, Leila Baghernajad& Sarta, Simona& Cassone, Marco& Capogna, Maria Vittoria& Piccione, Emilio…[et al.]. 2015. A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature. Case Reports in Obstetrics and Gynecology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059219
Modern Language Association (MLA)
Pirollo, Linda Maria Azzurra…[et al.]. A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature. Case Reports in Obstetrics and Gynecology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059219
American Medical Association (AMA)
Pirollo, Linda Maria Azzurra& Salehi, Leila Baghernajad& Sarta, Simona& Cassone, Marco& Capogna, Maria Vittoria& Piccione, Emilio…[et al.]. A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature. Case Reports in Obstetrics and Gynecology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059219