Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy
Joint Authors
Zyczynski, Laura E.
McHugh, Jonathan B.
Gribbin, Thomas E.
Schuetze, Scott M.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 69-year-old woman was diagnosed with alveolar rhabdomyosarcoma (ARMS) of the nasopharynx.
She has a history of catastrophic thromboembolic event in the abdomen that caused short-gut syndrome and dependence on total parenteral nutrition (TPN) twelve hours per day.
She was treated for short-gut syndrome with teduglutide, a glucagon-like peptide-2 (GLP-2) analog, which led to reduction of TPN requirements.
However, a few months later, she developed metastatic alveolar rhabdomyosarcoma.
Though a causative relationship is unlikely between the peptide and ARMS due to the brief time course between teduglutide therapy and sarcoma diagnosis, neoplastic growth may have been accelerated by the GLP-2 analog, causing release of IGF-1.
The transmembrane receptor for IGF-1 is frequently overexpressed in ARMS and is implicated in cell proliferation and metastatic behavior.
This case describes a rare incidence of metastatic alveolar rhabdomyosarcoma in a sexagenarian and possibly the first case reported associated with the use of teduglutide.
Teduglutide was discontinued due to a potential theoretical risk of acceleration of sarcoma growth, and the patient’s rhabdomyosarcoma is in remission following sarcoma chemotherapy.
American Psychological Association (APA)
Zyczynski, Laura E.& McHugh, Jonathan B.& Gribbin, Thomas E.& Schuetze, Scott M.. 2015. Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059236
Modern Language Association (MLA)
Zyczynski, Laura E.…[et al.]. Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059236
American Medical Association (AMA)
Zyczynski, Laura E.& McHugh, Jonathan B.& Gribbin, Thomas E.& Schuetze, Scott M.. Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059236