Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature

Abstract EN

Oxaliplatin is a common chemotherapy drug, used mainly for colon and gastric cancer.

Most common side effects are peripheral sensory neuropathy, hematological toxicity, and allergic reactions.

A less common side effect is pulmonary toxicity, characterized mainly by interstitial pneumonitis.

The incidence of this side effect is unknown, but the toxicity can be fatal.

Twenty-six cases of pulmonary toxicity have been described in the literature, seven in the setting of adjuvant treatment.

We describe two fatal cases of pulmonary injury related to oxaliplatin and a review of the literature.