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Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature
Joint Authors
Lim, Michael
Kleinberg, Lawrence
Khattab, Mohamed H.
Marciscano, Ariel E.
Lo, Simon S.
Laterra, John J.
Redmond, Kristin
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM.
Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases.
Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.
American Psychological Association (APA)
Khattab, Mohamed H.& Marciscano, Ariel E.& Lo, Simon S.& Lim, Michael& Laterra, John J.& Kleinberg, Lawrence…[et al.]. 2015. Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059279
Modern Language Association (MLA)
Khattab, Mohamed H.…[et al.]. Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059279
American Medical Association (AMA)
Khattab, Mohamed H.& Marciscano, Ariel E.& Lo, Simon S.& Lim, Michael& Laterra, John J.& Kleinberg, Lawrence…[et al.]. Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059279