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Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer
Joint Authors
Saif, Muhammad Wasif
De Souza, Andre
Daly, Kevin Pelham
Yoo, James
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
When associated with isolated four or fewer liver foci, metastatic colorectal cancer is amenable to surgical resection.
Alternative therapeutic methods for isolated liver metastases include radioembolization with yttrium 90 (Y90) and transarterial chemoembolization (TACE).
We present here a case of a patient with two sites of liver metastatic disease from colorectal cancer who underwent Y90 radioembolization combined with aflibercept and FOLFIRI.
Case Report.
A 56-year-old female with history of bilateral breast cancer and metastatic colon cancer with prior hemicolectomy and 4 previous chemotherapy regimens developed liver metastasis.
She was started on aflibercept and FOLFIRI and concurrently underwent two treatments of radioembolization with Y90, initially targeting the largest right lobe tumor, and then a subsequent treatment targeting the smaller left lobe tumor with retreatment of the right lobe tumor.
Her liver metastases exhibited partial response on imaging utilizing the modified RECIST criteria.
Interestingly, the patient CEA levels decreased after the procedure.
Discussion.
This is the first reported case of a patient managed with radioembolization with Y90 combined with aflibercept, an anti-VEGF treatment, and FOLFIRI.
An ongoing randomized clinical trial aims to define the role of combined targeted therapy and chemotherapy with radioembolization with Y90.
American Psychological Association (APA)
De Souza, Andre& Daly, Kevin Pelham& Yoo, James& Saif, Muhammad Wasif. 2015. Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059282
Modern Language Association (MLA)
De Souza, Andre…[et al.]. Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1059282
American Medical Association (AMA)
De Souza, Andre& Daly, Kevin Pelham& Yoo, James& Saif, Muhammad Wasif. Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059282