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Alternative Therapy for Epstein-Barr Virus Related Hemophagocytic Lymphohistiocytosis
Joint Authors
Markowitz, Avi
Al Asad, Omar
Salam, Amir
Mannem, Siva
Ninan, Mary
Jana, Bagi
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-08
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Hemophagocytic lymphohistiocytosis (HLH) is a rapidly fatal condition characterized by excessive immune activation.
HLH can occur as a familial or sporadic acquired disorder.
Acquired HLH is more frequently found in adults and is commonly secondary to infections, malignancies, or autoimmune diseases.
Diagnosing HLH is challenging because of the rare occurrence, variable presentation, and nonspecific findings of this disorder.
Diagnosis of HLH can be based on the diagnostic criteria which were used in the HLH-2004 trial.
Given the rarity of this disease, protocols for its treatment have developed slowly, and obtaining adequate short-term and long-term control of the disease continues to be a challenge.
Conventional induction therapy for HLH is dexamethasone and etoposide (VP-16), followed by or with cyclosporine.
Intrathecal methotrexate ± hydrocortisone is given to those with central nervous system disease.
We are reporting a patient who was diagnosed with Epstein-Barr virus (EBV) related HLH.
He achieved complete remission with rituximab alone.
To our knowledge, this is the first case of an adult patient with EBV related HLH who went into remission with rituximab therapy alone, without using the conventional chemotherapy.
American Psychological Association (APA)
Al Asad, Omar& Salam, Amir& Mannem, Siva& Ninan, Mary& Markowitz, Avi& Jana, Bagi. 2015. Alternative Therapy for Epstein-Barr Virus Related Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059285
Modern Language Association (MLA)
Al Asad, Omar…[et al.]. Alternative Therapy for Epstein-Barr Virus Related Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1059285
American Medical Association (AMA)
Al Asad, Omar& Salam, Amir& Mannem, Siva& Ninan, Mary& Markowitz, Avi& Jana, Bagi. Alternative Therapy for Epstein-Barr Virus Related Hemophagocytic Lymphohistiocytosis. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1059285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059285