Primary Mediastinal Synovial Sarcoma Presenting as Superior Vena Cava Syndrome: A Rare Case Report and Review of the Literature
Joint Authors
Modi, Gaurang
Panchal, Harsha
Anand, Asha
Parikh, Sonia
Revannasiddaiah, Swaroop
Shah, Sandip
Sarkar, Malay
Kataria, Pritam
Kulkarni, Rahul
Madabhavi, Irappa
Patel, Apurva
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Primary mediastinal sarcomas are aggressive tumors with a very rare incidence.
This report describes the case of a 35-year-old male patient who presented with acute symptoms of dyspnoea, facial puffiness, voice-hoarseness, and engorged neck veins.
With the clinical picture consistent with the superior vena cava (SVC) syndrome, the patient was investigated with computed tomography of the chest.
This revealed a large soft tissue density mass lesion compressing the SVC along with other critical superior mediastinal structures.
Histopathological evaluation of the mass revealed features consistent with a soft tissue sarcoma and positive staining was observed for vimentin and S-100.
Cytogenetic analysis by fluorescent in situ hybridisation (FISH) demonstrated the t(X:18) translocation.
Thus diagnosis was established as primary mediastinal synovial sarcoma.
Patient was treated with three cycles of neoadjuvant chemotherapy, to which there was a partial response as per the RECIST criteria.
Surgical excision of the mediastinal mass was performed, and further postoperative treatment with adjuvant chemoradiotherapy was provided.
Patient currently is free of disease.
This is to the best of our knowledge the first report in the world literature of a successfully treated case of “primary mediastinal sarcomas presenting as SVC syndrome.” Patient is under regular surveillance at our clinic and remains free of recurrence one year after treatment completion.
American Psychological Association (APA)
Madabhavi, Irappa& Kataria, Pritam& Patel, Apurva& Revannasiddaiah, Swaroop& Anand, Asha& Panchal, Harsha…[et al.]. 2015. Primary Mediastinal Synovial Sarcoma Presenting as Superior Vena Cava Syndrome: A Rare Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059303
Modern Language Association (MLA)
Madabhavi, Irappa…[et al.]. Primary Mediastinal Synovial Sarcoma Presenting as Superior Vena Cava Syndrome: A Rare Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059303
American Medical Association (AMA)
Madabhavi, Irappa& Kataria, Pritam& Patel, Apurva& Revannasiddaiah, Swaroop& Anand, Asha& Panchal, Harsha…[et al.]. Primary Mediastinal Synovial Sarcoma Presenting as Superior Vena Cava Syndrome: A Rare Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059303