PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C andor HIV
Joint Authors
Wilson, Melissa
Pruckner, Chelsea
Kirkwood, John M.
Davar, Diwakar
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
On the basis of remarkable antitumor activity, programmed death receptor-1 (PD-1) inhibitors pembrolizumab and nivolumab were approved for the treatment of advanced melanoma in the second-line setting following progression on either CTLA-4 inhibitor ipilimumab or BRAF/MEK inhibitors (for BRAF mutated melanoma).
Given hypothesized risk of triggering exacerbations of autoimmune diseases and/or chronic viral infections, clinical trials (including regulatory studies) evaluating checkpoint blocking antibodies PD-1 and CTLA-4 have excluded patients with autoimmune diseases, chronic hepatitis B/C virus (HBV/HCV), and/or human immunodeficiency virus (HIV) infections.
Herein, we describe two patients with advanced melanoma and concomitant HCV/HIV infections treated with PD-1 inhibitor pembrolizumab.
Patient 2 with HIV/HCV coinfection progressed after 2 doses of pembrolizumab.
Patient 1 who had HCV alone was treated with pembrolizumab with initial partial response.
HCV viral load remained stable after 9 cycles of pembrolizumab following which 12-week course of HCV-directed therapy was commenced, resulting in prompt reduction of HCV viral load below detectable levels.
Response is ongoing and HCV viral load remains undetectable.
In both patients, no significant toxicities were observed when pembrolizumab was initiated.
We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.
American Psychological Association (APA)
Davar, Diwakar& Wilson, Melissa& Pruckner, Chelsea& Kirkwood, John M.. 2015. PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C andor HIV. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059308
Modern Language Association (MLA)
Davar, Diwakar…[et al.]. PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C andor HIV. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059308
American Medical Association (AMA)
Davar, Diwakar& Wilson, Melissa& Pruckner, Chelsea& Kirkwood, John M.. PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C andor HIV. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059308