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Late Onset Ipilimumab-Induced Pericarditis and Pericardial Effusion: A Rare but Life Threatening Complication
Joint Authors
Yun, Seongseok
Mansour, Iyad
Vincelette, Nicole D.
Hariri, Dana
Motamed, Sara
Source
Case Reports in Oncological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Metastatic cutaneous melanoma has poor prognosis with 2-year survival rate of 10–20%.
Melanoma cells express various antigens including gp100, melanoma antigen recognized by T cells 1 (MART-1), and tyrosinase, which can induce immune-mediated anticancer response via T cell activation.
Cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) is an immune check point molecule that negatively regulates T cell activation and proliferation.
Accordingly, recent phase III clinical trials demonstrated significant survival benefit with ipilimumab, a human monoclonal antibody (IgG1) that blocks the interaction of CTLA-4 with its ligands.
Since the efficacy of ipilimumab depends on T cell activation, it is associated with substantial risk of immune mediated adverse reactions such as colitis, hepatitis, thyroiditis, and hypophysitis.
We report the first case of late onset pericarditis and cardiac tamponade associated with ipilimumab treatment in patient with metastatic cutaneous melanoma.
American Psychological Association (APA)
Yun, Seongseok& Vincelette, Nicole D.& Mansour, Iyad& Hariri, Dana& Motamed, Sara. 2015. Late Onset Ipilimumab-Induced Pericarditis and Pericardial Effusion: A Rare but Life Threatening Complication. Case Reports in Oncological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059311
Modern Language Association (MLA)
Yun, Seongseok…[et al.]. Late Onset Ipilimumab-Induced Pericarditis and Pericardial Effusion: A Rare but Life Threatening Complication. Case Reports in Oncological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059311
American Medical Association (AMA)
Yun, Seongseok& Vincelette, Nicole D.& Mansour, Iyad& Hariri, Dana& Motamed, Sara. Late Onset Ipilimumab-Induced Pericarditis and Pericardial Effusion: A Rare but Life Threatening Complication. Case Reports in Oncological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059311