Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature
Joint Authors
Miyazaki, Masaru
Ohtsuka, Masayuki
Tanaka, Kei
Kishimoto, Takashi
Nakatani, Yukio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We report a case of pancreatic hamartoma-like solitary fibrous tumor which was differentiated from pancreatic hamartoma with the detection of NAB2-STAT6 fusion, a specific mutation for solitary fibrous tumors.
A pancreatic well-demarcated solid nodule, 21 × 17 mm, of 82-year-old man was surgically enucleated.
Microscopic findings were close to a pancreatic hamartoma that consisted of sparsely distributed pancreatic ducts and acini in heavily collagenized fibrous stroma.
Neither islet nor peripheral nerve existed in the tumor.
The fibroblastic cells in the stroma were immune-positive for CD34, CD99, and bcl-2.
But these expressions were not decisive in the differentiation between solitary fibrous tumor and pancreatic hamartoma, because CD34 was positive for both tumors, and CD99 and bcl-2 expressions were not elucidated in the previous cases of pancreatic hamartomas.
Thus, we evaluated NAB2-STAT6 fusion.
The fibroblastic cells were positive for STAT6 and sequencing analysis revealed the gene fusion between NAB2 exon 4 and STAT6 exon 2, with which the final diagnos is of solitary fibrous tumor was achieved.
In conclusion, detection of NAB2-STAT6 fusion has a great diagnostic value for pancreatic solitary fibrous tumors with hamartoma-like features.
American Psychological Association (APA)
Tanaka, Kei& Kishimoto, Takashi& Ohtsuka, Masayuki& Nakatani, Yukio& Miyazaki, Masaru. 2015. Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature. Case Reports in Pathology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059690
Modern Language Association (MLA)
Tanaka, Kei…[et al.]. Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature. Case Reports in Pathology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1059690
American Medical Association (AMA)
Tanaka, Kei& Kishimoto, Takashi& Ohtsuka, Masayuki& Nakatani, Yukio& Miyazaki, Masaru. Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature. Case Reports in Pathology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059690