Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis
Joint Authors
Nassiri, Mehdi
Wang, Dehua
Zhou, Jiehao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
EBV associated hemophagocytic lymphohistiocytosis and EBV-positive T cell lymphoproliferative disease of childhood share many histologic and clinical features, which sometimes makes it very difficult to render a definitive diagnosis.
In this report, we present a 16-year-old male who developed symptoms clinically consistent with EBV associated hematophagocytic lymphohistiocytosis including fulfilling most of HLH diagnostic criteria and responding promptly to HLH targeted therapy.
However, histologic and cytogenetics features of this case are very concerning for EBV-positive T cell lymphoproliferative disease of childhood.
This case demonstrates an ambiguous boundary of these two disease entities and emphasizes the importance of comprehensive evaluation and clinical correlation with cases suspicious of EBV driven hemophagocytic or lymphoproliferative process.
American Psychological Association (APA)
Zhou, Jiehao& Wang, Dehua& Nassiri, Mehdi. 2015. Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Pathology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059714
Modern Language Association (MLA)
Zhou, Jiehao…[et al.]. Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Pathology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1059714
American Medical Association (AMA)
Zhou, Jiehao& Wang, Dehua& Nassiri, Mehdi. Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis. Case Reports in Pathology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1059714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059714