Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern
Joint Authors
Rodríguez-Urrego, P. A.
Castro-Villabón, Diana
Hudacko, Rachel
Álvarez, Johanna
Barrera, L.
Andrade, R.
López, R.
Vera, A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Fibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics.
It is usually seen in young adults without underlying liver disease.
Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis.
In contrast, classical hepatocellular carcinoma (HCC) is typically present in elderly male patients with cirrhosis.
It is the most common histological subtype, and it is characterized by its resemblance to the normal liver, both in its growth pattern and its cytology.
The unusual case of a liver carcinoma that presented with histological features of both FLC and classical HCC is herein reported.
This was the case of a 37-year-old female complaining of diffuse abdominal discomfort and epigastric pain for two months.
She was referred to us for further management after she was diagnosed with HCC in a noncirrhotic liver.
She underwent a left-sided hepatectomy.
A yellow nodular mass with well-defined borders and a necrotic center was present in the resection specimen.
The morphological features and immunohistochemical studies were consistent with a diagnosis of FLC mixed with classical HCC.
The patient was followed up for five months, and no signs of recurrence were evident.
American Psychological Association (APA)
Castro-Villabón, Diana& Barrera, L.& Rodríguez-Urrego, P. A.& Hudacko, Rachel& Vera, A.& Álvarez, Johanna…[et al.]. 2015. Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern. Case Reports in Pathology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059722
Modern Language Association (MLA)
Castro-Villabón, Diana…[et al.]. Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern. Case Reports in Pathology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059722
American Medical Association (AMA)
Castro-Villabón, Diana& Barrera, L.& Rodríguez-Urrego, P. A.& Hudacko, Rachel& Vera, A.& Álvarez, Johanna…[et al.]. Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern. Case Reports in Pathology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059722