A Histologically Diagnosed Case with Infantile Osteopetrosis Complicated by Hypopituitarism
Joint Authors
Diniz, Gulden
Altay, Canan
Calkavur, Sebnem
Olukman, Ozgur
Buyukinan, Muammer
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Malignant infantile osteopetrosis is a rarely seen severe disorder which appears early in life with general sclerosis of the skeleton.
It is caused by functionally defective osteoclasts which fail to resorb bone.
Affected infants can exhibit a wide spectrum of clinical manifestations including impaired hematopoiesis, hepatosplenomegaly, visual impairment, and hypocalcemia.
With the exception of secondary hyperparathyroidism, involvement of the endocrine system seems to be quite rare.
Hypopituitarism is defined as underproduction of the growth hormone in combination with deficiencies of other pituitary hormones.
Any lesion that damages hypothalamus, pituitary stalk, or anterior pituitary can cause secondary hypopituitarism.
In this report, we presented a rare combination of malignant infantile osteopetrosis and secondary hypopituitarism in a newborn who presented predominantly with endocrinological symptoms.
This is the first case report of malignant infantile osteopetrosis accompanied by hypopituitarism secondary to sclerosis of the sella turcica.
On the other hand, this is a very interesting case which was diagnosed based on histological examination of bone marrow biopsy specimens despite lack of any clinical suspicion.
American Psychological Association (APA)
Diniz, Gulden& Olukman, Ozgur& Calkavur, Sebnem& Buyukinan, Muammer& Altay, Canan. 2015. A Histologically Diagnosed Case with Infantile Osteopetrosis Complicated by Hypopituitarism. Case Reports in Pathology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059734
Modern Language Association (MLA)
Diniz, Gulden…[et al.]. A Histologically Diagnosed Case with Infantile Osteopetrosis Complicated by Hypopituitarism. Case Reports in Pathology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059734
American Medical Association (AMA)
Diniz, Gulden& Olukman, Ozgur& Calkavur, Sebnem& Buyukinan, Muammer& Altay, Canan. A Histologically Diagnosed Case with Infantile Osteopetrosis Complicated by Hypopituitarism. Case Reports in Pathology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059734