Amisulpride Augmentation for Clozapine-Refractory Positive Symptoms: Additional Benefit in Reducing Hypersialorrhea

Abstract EN

One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment.

Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients.

This is a case of a 30-year-old male with refractory schizophrenia; in this patient, the remission of residual positive symptoms, as well as the reduction of CIH, was achieved by treatment with clozapine augmented with amisulpride.