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Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations
Joint Authors
Burkart, Jarred
Ozkan, Efe
Ajam, Amna
Zhao, Weiqiang
Otterson, Gregory A.
Shilo, Konstantin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The case reported is a young “light” ex-smoker who initially had a localized adenosquamous carcinoma bearing an epidermal growth factor receptor (EGFR) sensitizing mutation.
He first recurred six months after initial treatment within the brain with a pure squamous histology and the same EGFR mutation.
Surgical resection and radiation rendered him disease-free.
Subsequent isolated recurrence within the lung eighteen months later was a pure adenocarcinoma, again with the same identified EGFR mutation.
These histologic changes (from adenosquamous to pure squamous to pure adenocarcinoma) have been described but not before in the absence of any selection pressure with EGFR tyrosine kinase inhibitors.
This case points out the histologic “flexibility” of EGFR mutant lung cancers and the importance for appropriate molecular testing in nonsmokers with lung cancer of any histologic type.
American Psychological Association (APA)
Burkart, Jarred& Shilo, Konstantin& Zhao, Weiqiang& Ozkan, Efe& Ajam, Amna& Otterson, Gregory A.. 2015. Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations. Case Reports in Pulmonology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059863
Modern Language Association (MLA)
Burkart, Jarred…[et al.]. Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations. Case Reports in Pulmonology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059863
American Medical Association (AMA)
Burkart, Jarred& Shilo, Konstantin& Zhao, Weiqiang& Ozkan, Efe& Ajam, Amna& Otterson, Gregory A.. Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations. Case Reports in Pulmonology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059863