Pulmonary Peripheral Carcinoids after Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Tumorlets: Report of 3 Cases

Joint Authors

Abrantes, Carlos
Oliveira, Rui Caetano
Saraiva, Joana
Bernardo, João
Carvalho, Lina

Source

Case Reports in Pulmonology

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-11-03

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and tumorlets are neuroendocrine cells proliferations smaller than 5 mm.

The former confines to bronchial/bronchiolar wall, while the latter broke through epithelial basement membrane.

The authors present 3 cases of DIPNECH and tumorlets associated with a typical peripheral carcinoid tumor without underlying lung disease.

The patients presented with nonspecific pulmonary symptoms: 3 females, 60, 72, and 84 years old, whose CT-scans showed well-defined pulmonary nodules, 2.2, 1.6, and 1.4 cm, respectively; first patient was submitted to lobectomy and the others underwent surgical biopsy.

Whitish/brownish lobulated tumors corresponded to typical carcinoids (less than 2 mitoses/2 mm2 and without necrosis); polygonal/elongated cells under lobular pattern expressed CD56, chromogranin A, synaptophysin, and CK7; Ki-67 positivity was between 1 and 3%.

Bronchial/bronchiolar wall neuroendocrine cell hyperplasia and several neuroendocrine nodules under 5 mm, with identical morphologic and immunoexpression, were observed, without lung disease.

Typical carcinoid associated with DIPNECH and tumorlets without other pulmonary diseases is rare.

Sporadic cases may recall embryonal neuroendocrine differentiation potentiality to develop peripheral hyperplasia, most commonly in underoxygenated parenchyma.

The described cases are elucidative of peripheral spectrum of neuroendocrine cell tumour evolution, reinforcing higher female incidence as in central carcinoids, still without a clear preneoplastic lesion.

American Psychological Association (APA)

Abrantes, Carlos& Oliveira, Rui Caetano& Saraiva, Joana& Bernardo, João& Carvalho, Lina. 2015. Pulmonary Peripheral Carcinoids after Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Tumorlets: Report of 3 Cases. Case Reports in Pulmonology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059889

Modern Language Association (MLA)

Abrantes, Carlos…[et al.]. Pulmonary Peripheral Carcinoids after Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Tumorlets: Report of 3 Cases. Case Reports in Pulmonology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1059889

American Medical Association (AMA)

Abrantes, Carlos& Oliveira, Rui Caetano& Saraiva, Joana& Bernardo, João& Carvalho, Lina. Pulmonary Peripheral Carcinoids after Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Tumorlets: Report of 3 Cases. Case Reports in Pulmonology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1059889

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1059889