Effectiveness of Certolizumab Pegol in Treating Rheumatoid Arthritis Patients with Persistent Inflamed Residual Mono- or Oligosynovitis Resistant to Prior TNF-α Inhibitors
Joint Authors
Ohta, Akihide
Koarada, Syuichi
Tsuboi, Masahiko
Komine, Mitsunori
Nakao, Yoshinobu
Tokuda, Yukiko
Ono, Yukihide
Tashiro, Satoko
Maruyama, Akihito
Ono, Nobuyuki
Tada, Yoshifumi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We report four cases of successful treatment with certolizumab pegol (CZP) of rheumatoid arthritis (RA) patients with persistent inflamed residual mono- or oligosynovitis resistant to prior TNF-α inhibitors.
Although the patients were in a moderate disease activity, a low activity, or a remission of RA, they sustained inflammatory mono-/oligoarthritis even after treatment with prior TNF inhibitors.
They were then all treated with CZP and observed in a serial ultrasonography.
In all cases, the positive power Doppler signals in the joint have disappeared promptly and all of the patients were able to retain remission in the long term.
The treatment of CZP to the refractory mono-/oligoarthritis of inflammatory synovitis in RA patients has not been previously described.
The cases suggest that it may be associated with the feature of CZP, possible effective penetration into the site of inflammation.
American Psychological Association (APA)
Koarada, Syuichi& Tsuboi, Masahiko& Komine, Mitsunori& Nakao, Yoshinobu& Tokuda, Yukiko& Ono, Yukihide…[et al.]. 2015. Effectiveness of Certolizumab Pegol in Treating Rheumatoid Arthritis Patients with Persistent Inflamed Residual Mono- or Oligosynovitis Resistant to Prior TNF-α Inhibitors. Case Reports in Rheumatology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059966
Modern Language Association (MLA)
Koarada, Syuichi…[et al.]. Effectiveness of Certolizumab Pegol in Treating Rheumatoid Arthritis Patients with Persistent Inflamed Residual Mono- or Oligosynovitis Resistant to Prior TNF-α Inhibitors. Case Reports in Rheumatology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059966
American Medical Association (AMA)
Koarada, Syuichi& Tsuboi, Masahiko& Komine, Mitsunori& Nakao, Yoshinobu& Tokuda, Yukiko& Ono, Yukihide…[et al.]. Effectiveness of Certolizumab Pegol in Treating Rheumatoid Arthritis Patients with Persistent Inflamed Residual Mono- or Oligosynovitis Resistant to Prior TNF-α Inhibitors. Case Reports in Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059966