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Early-Onset Neutropenia Induced by Rituximab in a Patient with Lupus Nephritis and Hemolytic Anemia
Joint Authors
Arroyo-Ávila, Mariangelí
Fred-Jiménez, Ruth M.
Vilá, Luis M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Rituximab is an anti-CD20 monoclonal antibody that has been used to treat several complications of systemic lupus erythematosus (SLE) including nephritis, cerebritis, and hematological disorders.
Neutropenia is among the adverse events associated with rituximab; this usually occurs several weeks after therapy.
However, early-onset neutropenia has been reported only in a few cases.
Herein, we describe a 36-year-old Hispanic SLE woman who developed severe early-onset neutropenia (0.3 × 109/L) after the second weekly rituximab infusion (375 mg/m2 weekly × 4) given for nephritis and hemolytic anemia.
She also had early-onset thrombocytopenia after rituximab therapy.
Both hematological disorders resolved 12 days after the fourth and final dose.
This case, together with few others, suggests that early-onset neutropenia may occur during rituximab therapy.
Even though rituximab-induced neutropenia seems to be transient, it may predispose SLE patients to severe complications such as infections.
American Psychological Association (APA)
Arroyo-Ávila, Mariangelí& Fred-Jiménez, Ruth M.& Vilá, Luis M.. 2015. Early-Onset Neutropenia Induced by Rituximab in a Patient with Lupus Nephritis and Hemolytic Anemia. Case Reports in Rheumatology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059978
Modern Language Association (MLA)
Arroyo-Ávila, Mariangelí…[et al.]. Early-Onset Neutropenia Induced by Rituximab in a Patient with Lupus Nephritis and Hemolytic Anemia. Case Reports in Rheumatology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1059978
American Medical Association (AMA)
Arroyo-Ávila, Mariangelí& Fred-Jiménez, Ruth M.& Vilá, Luis M.. Early-Onset Neutropenia Induced by Rituximab in a Patient with Lupus Nephritis and Hemolytic Anemia. Case Reports in Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1059978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059978