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Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease
Joint Authors
Kaji, Mariko
Kishi, Takayuki
Miyamae, Takako
Nagata, Satoru
Yamanaka, Hisashi
Fujikawa, Satoshi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We describe our experience with a juvenile patient who had refractory intestinal Behcet’s disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor.
The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lower extremities.
She gradually developed a low-grade fever, abdominal pain, diarrhea, and hematochezia.
Lower gastrointestinal endoscopy revealed ulcers in the terminal ileum, consistent with intestinal Behcet’s disease.
Methylprednisolone pulse therapy was initiated, after which the symptoms transiently improved, but, during the corticosteroid taper, the abdominal pain recurred.
The symptoms resolved soon after the administration of adalimumab.
Of importance, the dose of corticosteroids was successfully reduced without exacerbation during 8 months of observation.
This is the first reported case in which adalimumab was used for pediatric gastrointestinal Behcet’s disease.
Adalimumab is a good choice for intestinal Behcet’s disease refractory to conventional treatment.
American Psychological Association (APA)
Kaji, Mariko& Kishi, Takayuki& Miyamae, Takako& Nagata, Satoru& Yamanaka, Hisashi& Fujikawa, Satoshi. 2015. Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease. Case Reports in Rheumatology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059979
Modern Language Association (MLA)
Kaji, Mariko…[et al.]. Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease. Case Reports in Rheumatology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059979
American Medical Association (AMA)
Kaji, Mariko& Kishi, Takayuki& Miyamae, Takako& Nagata, Satoru& Yamanaka, Hisashi& Fujikawa, Satoshi. Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease. Case Reports in Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059979