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A Case of Docetaxel Induced Myositis and Review of the Literature
Joint Authors
Perel-Winkler, Alexandra Caitlin
Belokovskaya, Regina
Amigues, Isabelle
Larusso, Melissa
Hussain, Nazia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention.
With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common complaints, the later with unexplained pathophysiology.
We report a 65-year-old Hispanic woman with estrogen receptor (ER) and progesterone receptor (PR) positive invasive ductal breast carcinoma who presented with right thigh pain and swelling eight days after her third infusion of docetaxel (a taxane chemotherapeutic) and cyclophosphamide.
Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs.
A workup to rule out other causes of myositis was negative.
Docetaxel was not reintroduced and the patient improved with corticosteroids.
Since 2005 this is, to our knowledge, the fifth reported case of docetaxel related inflammatory myositis.
Taxanes have been noted to cause disabling but transient arthralgias and myalgias; it is important to consider the possibility of inflammatory myopathy as a possible complication in patients undergoing treatment with these agents.
American Psychological Association (APA)
Perel-Winkler, Alexandra Caitlin& Belokovskaya, Regina& Amigues, Isabelle& Larusso, Melissa& Hussain, Nazia. 2015. A Case of Docetaxel Induced Myositis and Review of the Literature. Case Reports in Rheumatology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059984
Modern Language Association (MLA)
Perel-Winkler, Alexandra Caitlin…[et al.]. A Case of Docetaxel Induced Myositis and Review of the Literature. Case Reports in Rheumatology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1059984
American Medical Association (AMA)
Perel-Winkler, Alexandra Caitlin& Belokovskaya, Regina& Amigues, Isabelle& Larusso, Melissa& Hussain, Nazia. A Case of Docetaxel Induced Myositis and Review of the Literature. Case Reports in Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1059984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059984