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Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation
Joint Authors
Querido, Sara
Sousa, Henrique Silva
Pereira, Tiago Assis
Birne, Rita
Matias, Patrícia
Jorge, Cristina
Weigert, André
Adragão, Teresa
Bruges, Margarida
Machado, Domingos
Source
Case Reports in Transplantation
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 56-year-old African patient received a kidney from a deceased donor with 4 HLA mismatches in April 2013.
He received immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil, and prednisone.
Immediate diuresis and a good allograft function were soon observed.
Six months later, the serum creatinine level increased to 2.6 mg/dL.
A renal allograft biopsy revealed interstitial fibrosis and tubular atrophy grade II.
Toxicity of calcineurin inhibitor was assumed and, after a switch for everolimus, renal function improved.
However, since March 2014, renal function progressively deteriorated.
A second allograft biopsy showed no new lesions.
Two months later, the patient was admitted due to anuria, haematochezia with anaemia, requiring 5 units of packed red blood cells, and diffuse skin thickening.
Colonoscopy showed haemorrhagic patches in the colon and the rectum; histology diagnosis was Kaposi sarcoma (KS).
A skin biopsy revealed cutaneous involvement of KS.
Rapid clinical deterioration culminated in death in June 2014.
This case is unusual as less than 20 cases of KS with gross gastrointestinal bleeding have been reported and only 6 cases had the referred bleeding originating in the lower gastrointestinal tract.
So, KS should be considered in differential diagnosis of gastrointestinal bleeding in some kidney transplant patients.
American Psychological Association (APA)
Querido, Sara& Sousa, Henrique Silva& Pereira, Tiago Assis& Birne, Rita& Matias, Patrícia& Jorge, Cristina…[et al.]. 2015. Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation. Case Reports in Transplantation،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060187
Modern Language Association (MLA)
Querido, Sara…[et al.]. Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation. Case Reports in Transplantation No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1060187
American Medical Association (AMA)
Querido, Sara& Sousa, Henrique Silva& Pereira, Tiago Assis& Birne, Rita& Matias, Patrícia& Jorge, Cristina…[et al.]. Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation. Case Reports in Transplantation. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060187