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Treatment of Recurrent Posttransplant Lymphoproliferative Disorder with Autologous Blood Stem Cell Transplant
Joint Authors
Rahal, Ahmad K.
Kallail, K. James
Malhotra, Bharat
Farhoud, Hussam
Moore , Dennis F.
Source
Case Reports in Transplantation
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Posttransplant lymphoproliferative disorders (PTLDs) occur after solid organ transplantation.
Treatment guidelines include reduction in immunosuppression (RIS), radiation, rituximab, chemotherapy, and immunological agents.
We present a rare case of recurrent diffuse large B-cell lymphoma presenting as a PTLD in a heart transplant patient treated with autologous blood stem cell transplant (ASCT) after failure of conventional therapy.
Case Presentation.
A 66-year-old male presented with a neck mass.
He has a history of Hodgkin’s disease status after staging laparotomy with splenectomy and heart transplantation due to dilated nonischemic cardiomyopathy 8 years prior to the development of PTLD.
His examination was remarkable for right submandibular swelling.
An excisional biopsy confirmed the diagnosis of diffuse large B-cell NHL.
Patient received RIS, rituximab, chemotherapy, and radiation therapy with a complete remission.
His lymphoma relapsed and he subsequently was treated with RICE salvage chemotherapy and consolidative high-dose chemotherapy with BEAC regimen followed by ASCT resulting in a complete remission.
Conclusion.
Patients with PTLD present a difficult therapeutic challenge.
In this case, the patient’s prior history of Hodgkin’s disease, splenectomy, and a heart transplant appear to be unique features, the significance of which is unclear.
ASCT might be a promising therapy for patients with relapsed or refractory PTLD.
American Psychological Association (APA)
Malhotra, Bharat& Rahal, Ahmad K.& Farhoud, Hussam& Moore , Dennis F.& Kallail, K. James. 2015. Treatment of Recurrent Posttransplant Lymphoproliferative Disorder with Autologous Blood Stem Cell Transplant. Case Reports in Transplantation،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1060196
Modern Language Association (MLA)
Malhotra, Bharat…[et al.]. Treatment of Recurrent Posttransplant Lymphoproliferative Disorder with Autologous Blood Stem Cell Transplant. Case Reports in Transplantation No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1060196
American Medical Association (AMA)
Malhotra, Bharat& Rahal, Ahmad K.& Farhoud, Hussam& Moore , Dennis F.& Kallail, K. James. Treatment of Recurrent Posttransplant Lymphoproliferative Disorder with Autologous Blood Stem Cell Transplant. Case Reports in Transplantation. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1060196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060196