Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
Joint Authors
Karahan, Zülküf
Uğurlu, Murat
Uçaman, Berzal
Uluğ, Ali Veysel
Kaya, İlyas
Çevik, Kemal
Öztürk, Önder
Iyem, Hikmet
Source
Cardiology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system.
In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown.
However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known.
The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score.
In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score.
Blood samples were obtained from all patients in the first day.
The patients with ApoE34 genotype had high Gensini scores.
Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22).
The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.).
There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score.
But, the patients with E4 allele carriers were associated with high lipid levels.
American Psychological Association (APA)
Karahan, Zülküf& Uğurlu, Murat& Uçaman, Berzal& Uluğ, Ali Veysel& Kaya, İlyas& Çevik, Kemal…[et al.]. 2015. Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. Cardiology Research and Practice،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060360
Modern Language Association (MLA)
Karahan, Zülküf…[et al.]. Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. Cardiology Research and Practice No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1060360
American Medical Association (AMA)
Karahan, Zülküf& Uğurlu, Murat& Uçaman, Berzal& Uluğ, Ali Veysel& Kaya, İlyas& Çevik, Kemal…[et al.]. Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. Cardiology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060360