![](/images/graphics-bg.png)
Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population
Joint Authors
Zeng, Xianxu
Ban, Zhenying
Cao, Jing
Zhang, Wei
Chu, Tianjiao
Lei, Dongmei
Du, Yanmin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recently, several studies have reported associations between fat mass and obesity-associated (FTO) gene mutations and cancer susceptibility.
But little is known about their association with risk and survival of breast cancer in Chinese population.
The aim of this study is to examine whether cancer-related FTO polymorphisms are associated with risk and survival of breast cancer and BMI levels in controls in a Chinese population.
We genotyped six FTO polymorphisms in a case-control study, including 537 breast cancer cases and 537 controls.
FTO rs1477196 AA genotype had significant decreased breast cancer risk [odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.34–0.86] compared to GG genotype, and this association was only found in women with BMI < 24 kg/m2 (OR = 0.41, 95% CI: 0.22–0.76); and rs16953002 AA genotype conferred significant increased breast cancer risk (OR = 1.80, 95% CI: 1.23–2.63) compared to GG genotype.
Haplotype analysis showed that FTO TAC haplotype (rs9939609-rs1477196-rs1121980) had significant reduced breast cancer risk (OR = 0.76, 95% CI: 0.62–0.93) compared with TGC haplotype.
But we failed to find any association between FTO polymorphisms and breast cancer survival.
These findings suggest that variants in FTO gene may influence breast cancer susceptibility.
American Psychological Association (APA)
Zeng, Xianxu& Ban, Zhenying& Cao, Jing& Zhang, Wei& Chu, Tianjiao& Lei, Dongmei…[et al.]. 2015. Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060851
Modern Language Association (MLA)
Zeng, Xianxu…[et al.]. Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060851
American Medical Association (AMA)
Zeng, Xianxu& Ban, Zhenying& Cao, Jing& Zhang, Wei& Chu, Tianjiao& Lei, Dongmei…[et al.]. Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060851