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Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery
Joint Authors
Andalib, Iman
Shah, Hiral
Bal, Bikram S.
Shope, Timothy R.
Finelli, Frederick C.
Koch, Timothy R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Abdominal symptoms are common after bariatric surgery, and these individuals commonly have upper gut bacterial overgrowth, a known cause of malabsorption.
Breath hydrogen determination after oral glucose is a safe and inexpensive test for malabsorption.
This study is designed to investigate breath hydrogen levels after oral glucose in symptomatic individuals who had undergone Roux-en-Y gastric bypass surgery.
Methods.
This is a retrospective study of individuals ( n = 63 ; 60 females; 3 males; mean age 49 years) who had gastric bypass surgery and then glucose breath testing to evaluate abdominal symptoms.
Results.
Among 63 postoperative individuals, 51 (81%) had a late rise ( ≥ 45 minutes) in breath hydrogen or methane, supporting glucose malabsorption; 46 (90%) of these 51 subjects also had an early rise ( ≤ 30 minutes) in breath hydrogen or methane supporting upper gut bacterial overgrowth.
Glucose malabsorption was more frequent in subjects with upper gut bacterial overgrowth compared to subjects with no evidence for bacterial overgrowth ( P < 0.001 ).
Conclusion.
These data support the presence of intestinal glucose malabsorption associated with upper gut bacterial overgrowth in individuals with abdominal symptoms after gastric bypass surgery.
Breath hydrogen testing after oral glucose should be considered to evaluate potential malabsorption in symptomatic, postoperative individuals.
American Psychological Association (APA)
Andalib, Iman& Shah, Hiral& Bal, Bikram S.& Shope, Timothy R.& Finelli, Frederick C.& Koch, Timothy R.. 2015. Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060852
Modern Language Association (MLA)
Andalib, Iman…[et al.]. Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060852
American Medical Association (AMA)
Andalib, Iman& Shah, Hiral& Bal, Bikram S.& Shope, Timothy R.& Finelli, Frederick C.& Koch, Timothy R.. Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060852