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Validation of Serum Biomarkers Derived from Proteomic Analysis for the Early Screening of Preeclampsia
Joint Authors
Kolialexi, Aggeliki
Gourgiotis, Dimitrios
Daskalakis, George
Marmarinos, Antonis
Lykoudi, Alexandra
Mavreli, Danai
Mavrou, Ariadni
Papantoniou, Nikolas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To examine the potential value of previously identified biomarkers using proteomics in early screening for preeclampsia (PE).
Methods.
24 blood samples from women who subsequently developed PE and 48 from uncomplicated pregnancies were obtained at 11–13 weeks and analysed after delivery.
Cystatin-C, sVCAM-1, and Pappalysin-1 were quantified by ELISA.
Maternal characteristics and medical history were recorded.
Results.
Median values of Cystatin-C, sVCAM-1, and Pappalysin-1 in the PE group as compared to controls were 909.1 gEq/mL versus 480.0 gEq/mL, P = .
000 , 832.0 gEq/mL versus 738.8 gEq/mL, P = .
024 , and 234.4 gEq/mL versus 74.9 gEq/mL, P = .
064 , respectively.
Areas under the receiver-operating characteristic curves (AUC, standard error (SE)) for predicting PE were Cystatin-C: 0.90 (SE 0.04), VCAM-1: 0.66 (SE 0.074), and Pappalysin-1: 0.63 (SE 0.083).
To discriminate between cases at risk for PE and normal controls, cut-off values of 546.8 gEq/mL for Cystatin-C, 1059.5 gEq/mL for sVCAM-1, and 220.8 gEq/mL for Pappalysin-1 were chosen, providing sensitivity of 91%, 41%, and 54% and specificity of 85%, 100%, and 95%, respectively.
Conclusions.
sVCAM-1 and Pappalysin-1 do not improve early screening for PE.
Cystatin-C, however, seems to be associated with subsequent PE development, but larger studies are necessary to validate these findings.
American Psychological Association (APA)
Kolialexi, Aggeliki& Gourgiotis, Dimitrios& Daskalakis, George& Marmarinos, Antonis& Lykoudi, Alexandra& Mavreli, Danai…[et al.]. 2015. Validation of Serum Biomarkers Derived from Proteomic Analysis for the Early Screening of Preeclampsia. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060854
Modern Language Association (MLA)
Kolialexi, Aggeliki…[et al.]. Validation of Serum Biomarkers Derived from Proteomic Analysis for the Early Screening of Preeclampsia. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060854
American Medical Association (AMA)
Kolialexi, Aggeliki& Gourgiotis, Dimitrios& Daskalakis, George& Marmarinos, Antonis& Lykoudi, Alexandra& Mavreli, Danai…[et al.]. Validation of Serum Biomarkers Derived from Proteomic Analysis for the Early Screening of Preeclampsia. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060854