Matrix Metalloproteinase-9Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis
Joint Authors
Xu, Liyan
Li, Enmin
Liu, Ming-Fa
Hu, Yong-Yang
Jin, Tao
Xu, Ke
Wang, Shao-Hong
Du, Guang-Zhou
Li, Li-Yan
Xu, Hai-Xiong
Wu, Bingli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin (MMP-9/NGAL) complex activity is elevated in brain tumors and may serve as a molecular marker for brain tumors.
However, the relationship between MMP-9/NGAL activity in brain tumors and patient prognosis and treatment response remains unclear.
Here, we compared the clinical characteristics of glioma patients with the MMP-9/NGAL activity measured in their respective tumor and urine samples.
Using gelatin zymography assays, we found that MMP-9/NGAL activity was significantly increased in tumor tissues (TT) and preoperative urine samples (Preop-1d urine).
Activity was reduced by seven days after surgery (Postop-1w urine) and elevated again in cases of tumor recurrence.
The MMP-9/NGAL status correlated well with MRI-based tumor assessments.
These findings suggest that MMP-9/NGAL activity could be a novel marker to detect gliomas and predict the clinical outcome of patients.
American Psychological Association (APA)
Liu, Ming-Fa& Hu, Yong-Yang& Jin, Tao& Xu, Ke& Wang, Shao-Hong& Du, Guang-Zhou…[et al.]. 2015. Matrix Metalloproteinase-9Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060858
Modern Language Association (MLA)
Liu, Ming-Fa…[et al.]. Matrix Metalloproteinase-9Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060858
American Medical Association (AMA)
Liu, Ming-Fa& Hu, Yong-Yang& Jin, Tao& Xu, Ke& Wang, Shao-Hong& Du, Guang-Zhou…[et al.]. Matrix Metalloproteinase-9Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060858