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Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress
Joint Authors
Jarkovsky, Jiri
Tomandl, Josef
Tomandlova, Marie
Kubkova, Lenka
Kala, Petr
Littnerova, Simona
Gottwaldova, Jana
Kubena, Petr
Ganovska, Eva
Poloczek, Martin
Spinar, Jindrich
Mueller, Christian
Mebazaa, Alexandre
Pavkova Goldbergova, Monika
Parenica, Jiri
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Pentraxin-3 (PTX3) appears to have a cardioprotective effect through a positive influence against postreperfusion damage.
This study assesses the prognostic value of PTX3 level and its relationship with clinical parameters and markers of oxidative stress and nitric oxide metabolism in patients with ST-elevation myocardial infarction (STEMI).
Methods.
Plasma/serum levels of several biomarkers of inflammation and oxidative stress and nitrite/nitrate were assessed upon admission and 24 h after STEMI onset in patients treated by primary percutaneous coronary intervention.
Results.
ROC analysis showed that plasma PTX3 at 24 h was a strong predictor of 30-day and 1-year mortality and independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year.
The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-α, 8-hydroxy-2′-deoxyguanosine, and nitrite/nitrate.
Conclusions.
Plasma PTX3 at 24 h after STEMI onset is a strong predictor of 30-day and 1-year mortality.
PTX3 as a single biomarker is comparable with currently used scoring systems (TIMI or GRACE) or B-type natriuretic peptide.
PTX3 is also an independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year.
American Psychological Association (APA)
Tomandlova, Marie& Jarkovsky, Jiri& Tomandl, Josef& Kubkova, Lenka& Kala, Petr& Littnerova, Simona…[et al.]. 2015. Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060865
Modern Language Association (MLA)
Tomandlova, Marie…[et al.]. Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1060865
American Medical Association (AMA)
Tomandlova, Marie& Jarkovsky, Jiri& Tomandl, Josef& Kubkova, Lenka& Kala, Petr& Littnerova, Simona…[et al.]. Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060865