Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation
Joint Authors
Numakura, Kazuyuki
Kagaya, Hideaki
Yamamoto, Ryohei
Komine, Naoki
Saito, Mitsuru
Hiroshi, Tsuruta
Akihama, Susumu
Inoue, Takamitsu
Narita, Shintaro
Tsuchiya, Norihiko
Habuchi, Tomonori
Niioka, Takenori
Miura, Masatomo
Satoh, Shigeru
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We determined the prevalence of dyslipidemia in a Japanese cohort of renal allograft recipients and investigated clinical and genetic characteristics associated with having the disease.
In total, 126 patients that received renal allograft transplants between February 2002 and August 2011 were studied, of which 44 recipients (34.9%) were diagnosed with dyslipidemia at 1 year after transplantation.
Three clinical factors were associated with a risk of having dyslipidemia: a higher prevalence of disease observed among female than male patients P = 0.021 and treatment with high mycophenolate mofetil P = 0.012 and prednisolone P = 0.023 doses per body weight at 28 days after transplantation.
The genetic association between dyslipidemia and 60 previously described genetic polymorphisms in 38 putative disease-associated genes was analyzed.
The frequency of dyslipidemia was significantly higher in patients with the glucocorticoid receptor (NR3C1) Bcl1 G allele than in those with the CC genotype P = 0.001 .
A multivariate analysis revealed that the NR3C1 Bcl1 G allele was a significant risk factor for the prevalence of dyslipidemia (odds ratio = 4.6; 95% confidence interval = 1.8–12.2).
These findings may aid in predicting a patient’s risk of developing dyslipidemia.
American Psychological Association (APA)
Numakura, Kazuyuki& Kagaya, Hideaki& Yamamoto, Ryohei& Komine, Naoki& Saito, Mitsuru& Hiroshi, Tsuruta…[et al.]. 2015. Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060869
Modern Language Association (MLA)
Numakura, Kazuyuki…[et al.]. Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060869
American Medical Association (AMA)
Numakura, Kazuyuki& Kagaya, Hideaki& Yamamoto, Ryohei& Komine, Naoki& Saito, Mitsuru& Hiroshi, Tsuruta…[et al.]. Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060869