Anti-MUC1 Antibody in Nipple Aspirate Fluids Correlates with Tumor Aggressiveness in Breast Cancer: A Feasibility Study
Joint Authors
Menekşe, Ebru
McKolanis, John
Finn, Olivera J.
McAuliffe, Priscilla F.
Johnson, Ronald
Soran, Atilla
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Antibodies against MUC1 are found in circulation of breast cancer (BC) patients.
We hypothesized that anti-MUC1 antibodies might be present in even a higher concentration in nipple aspirate fluid (NAF) and could be used to predict aggressiveness of BC.
Serum and NAF samples were collected from high risk lesions, BC, and healthy contralateral breasts.
ELISA was used to measure the amount of IgG, IgM, and IgA against a tumor-specific MUC1 peptide derived from the extracellular tandem repeat domain of MUC1.
Tumor characteristics were recorded prospectively; 120 NAF samples were obtained from a total of 77 women in the study.
There was no significant difference of anti-MUC1 antibody levels compared to BC with other lesions.
Anti-MUC1 IgG level in NAF was higher in triple negative tumors ( P = 0.02 ); serum anti-MUC1 IgG levels were significantly higher in patients with ER (−) tumor and recurrent disease ( P = 0.01 ); NAF anti-MUC1 IgA levels were significantly higher in patients with LVI and Her2-neu (+) tumors ( P < 0.05 ).
These results show that NAF could be a reliable biomarker to predict tumor aggressiveness in BC.
A larger study will be needed to confirm these data and to investigate the potential of anti-MUC1 antibodies in NAF and serum to predict disease outcome.
American Psychological Association (APA)
Menekşe, Ebru& McKolanis, John& Finn, Olivera J.& McAuliffe, Priscilla F.& Johnson, Ronald& Soran, Atilla. 2015. Anti-MUC1 Antibody in Nipple Aspirate Fluids Correlates with Tumor Aggressiveness in Breast Cancer: A Feasibility Study. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060870
Modern Language Association (MLA)
Menekşe, Ebru…[et al.]. Anti-MUC1 Antibody in Nipple Aspirate Fluids Correlates with Tumor Aggressiveness in Breast Cancer: A Feasibility Study. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060870
American Medical Association (AMA)
Menekşe, Ebru& McKolanis, John& Finn, Olivera J.& McAuliffe, Priscilla F.& Johnson, Ronald& Soran, Atilla. Anti-MUC1 Antibody in Nipple Aspirate Fluids Correlates with Tumor Aggressiveness in Breast Cancer: A Feasibility Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060870