The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing
Joint Authors
Binder, Harald
Eipeldauer, Stefan
Gregori, Markus
Höchtl-Lee, Leonard
Thomas, Anita
Tiefenboeck, Thomas M.
Hajdu, Stefan
Sarahrudi, Kambiz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
Circulating levels of VEGF-A (Vascular Endothelia Growth Factor-A), TGF-β1 (Transforming Growth Factor-beta 1), and M-CSF (Macrophage-Colony Stimulating Factor) were found to be predictors of bone healing and therefore prognostic criteria of delayed bone healing or nonunion.
The aim of this study was to evaluate a potential rise of these markers in patients with multiple fractures of long bones compared to patients with single fractured long bone.
Methods.
92 patients were included in the study and finally after excluding all female patients 45 male patients were left for final analysis and divided into the single or multiple fracture group.
TGF-β1, M-CSF, and VEGF-A serum levels were analysed over a time period of two weeks.
Results.
MCSF serum concentrations were higher in the group with multiple fractures as also TGF-β1 serum concentrations were at one and two weeks after trauma.
No statistically significant difference was observed in the VEGF-A serum concentrations of both groups at either measurement point.
Conclusion.
We did observe a correlation between the quantity of the M-CSF and TGF-β1 expressions in serum and the number of fractured bones; surprisingly there was no statistically significant difference in the serum levels between patients with single and multiple fractures of long bones.
American Psychological Association (APA)
Binder, Harald& Eipeldauer, Stefan& Gregori, Markus& Höchtl-Lee, Leonard& Thomas, Anita& Tiefenboeck, Thomas M.…[et al.]. 2015. The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing. Disease Markers،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060877
Modern Language Association (MLA)
Binder, Harald…[et al.]. The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing. Disease Markers No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1060877
American Medical Association (AMA)
Binder, Harald& Eipeldauer, Stefan& Gregori, Markus& Höchtl-Lee, Leonard& Thomas, Anita& Tiefenboeck, Thomas M.…[et al.]. The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060877