![](/images/graphics-bg.png)
Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients
Joint Authors
Yahia Babiker, Ali Yousif
Rahmani, Arshad H.
AlWanian, Wanian M.
Elsiddig, Shawgi A.
Faragalla, Hassan E.
Aly, Salah M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of study was to examine the localization and distribution of cytokeratin (CK) and vimentin protein and their association with clinical outcome of the TCC patients.
Expression pattern of cytokeratin and vimentin was evaluated by immunohistochemistry in TCC cases and inflammatory lesions.
Cytoplasmic expression of CK was noticed in 52.17% of TCC cases and its expression was not observed in inflammatory lesions of bladder specimens.
Vimentin showed expression in 69.00% cases of TCC.
Significant differences were noticed in expression pattern of CK and vimentin in inflammatory lesion and Transitional Cell Carcinoma cases.
Vimentin expression increased with the grade of TCC and this difference was statistically significant whereas expression of CK decreased according to the grade of TCC.
Furthermore, it was also observed that expression pattern of vimentin was high in ≥55 years as compared to <55 age group patients and these differences were significant in men as compared to women.
Expression pattern of CK did not show any significant relation with age and gender.
Therefore, it can be concluded that cytokeratin and vimentin will be helpful markers in the early diagnosis of Transitional Cell Carcinoma/bladder carcinoma.
American Psychological Association (APA)
Rahmani, Arshad H.& Yahia Babiker, Ali Yousif& AlWanian, Wanian M.& Elsiddig, Shawgi A.& Faragalla, Hassan E.& Aly, Salah M.. 2015. Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients. Disease Markers،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060878
Modern Language Association (MLA)
Rahmani, Arshad H.…[et al.]. Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients. Disease Markers No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1060878
American Medical Association (AMA)
Rahmani, Arshad H.& Yahia Babiker, Ali Yousif& AlWanian, Wanian M.& Elsiddig, Shawgi A.& Faragalla, Hassan E.& Aly, Salah M.. Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060878