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Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-29 Exocytosis
Joint Authors
Lin, Shengtao
Jiang, Tao
Yu, Yang
Tang, Huamei
Lu, Su
Peng, Zhihai
Fan, Junwei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Emerging evidence shows that exocytosis plays a key role in tumor development and metastasis.
Secernin-1 (SCRN1) is a novel regulator of exocytosis.
Our previous work identified SCRN1 as a tumor-associated gene by bioinformatics analysis of transcriptomes.
In this study, we demonstrated the aberrant overexpression of SCRN1 at mRNA and protein level in colon cancer.
We also revealed that overexpression of SCRN1 was significantly associated with the tumor development and poor prognosis.
Experiments in vitro validated that SCRN1 may promote cancer cell proliferation and secretion of matrix metalloproteinase-2/9 (MMP-2/9) proteins to accelerate tumor progression.
American Psychological Association (APA)
Lin, Shengtao& Jiang, Tao& Yu, Yang& Tang, Huamei& Lu, Su& Peng, Zhihai…[et al.]. 2015. Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-29 Exocytosis. Disease Markers،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060879
Modern Language Association (MLA)
Lin, Shengtao…[et al.]. Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-29 Exocytosis. Disease Markers No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1060879
American Medical Association (AMA)
Lin, Shengtao& Jiang, Tao& Yu, Yang& Tang, Huamei& Lu, Su& Peng, Zhihai…[et al.]. Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-29 Exocytosis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060879