HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach
Joint Authors
Ieni, A.
Rigoli, L.
Caruso, R. A.
Barresi, Valeria
Tuccari, Giovanni
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab.
We reviewed the current knowledge on HER2 status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss the possible pathogenetic and prognostic roles of HER2 overexpression in GC.
Results.
HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia (HG-IEN), with higher frequency in gastric type dysplasia.
HER2 overexpression was significantly associated with disease recurrence and poor prognosis in EGC representing an independent risk factor for lymph node metastases.
HER2 overexpression was more frequent in AGC characterized by high grade, advanced stage, and high Ki-67 labeling index.
The discordance in HER2 status was evidenced between primitive GC and synchronous or metachronous metastases.
Conclusions.
HER2 overexpression in premalignant gastric lesions suggests its potential involvement in the early steps of gastric carcinogenesis.
The assessment of HER2 status in EGC may be helpful for the identification of patients who are at low risk for developing nodal metastases.
Finally, the possible discordance in HER2 status between primary GC and its synchronous metastases support routine assessment of HER2 both in the primary GC and in its metastatic lesions.
American Psychological Association (APA)
Ieni, A.& Barresi, Valeria& Rigoli, L.& Caruso, R. A.& Tuccari, Giovanni. 2015. HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060882
Modern Language Association (MLA)
Ieni, A.…[et al.]. HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060882
American Medical Association (AMA)
Ieni, A.& Barresi, Valeria& Rigoli, L.& Caruso, R. A.& Tuccari, Giovanni. HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060882