Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection
Joint Authors
Ishak, Ricardo
Souza Lima, Sandra
Feitosa, Rosimar Neris Martins
Azevedo, Vânia Nakauth
Ishak, Marluísa de O. Guimarães
Bonfim Freitas, Felipe
Rosário Vallinoto, Antonio Carlos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
This study investigated possible associations between the TNFα-308G/A, IFN+874A/T, IL-6-174C/G, IL-10-1082A/G, and TGF β -509C/T polymorphisms with HIV-1 infection, in addition to correlation of the polymorphisms with clinical markers of AIDS progression, such as levels of CD4+/CD8+ T lymphocytes and plasma viral load.
Methods.
A total of 216 individuals who were infected with HIV-1 and on antiretroviral therapy (ART) and 294 individuals from the uninfected control group were analyzed.
Results.
All individuals evaluated were negative for total anti-HBc, anti-HCV, anti-T.
pallidum, and anti-HTLV-1/2.
The polymorphisms were identified by PCR-RFLP.
Individuals presenting the IFN+874A allele as well as the AA genotype were more frequent in the HIV-1 infected group compared to the control group ( P < 0.05 ), in addition to having lower levels of CD4+ T lymphocytes.
The CD8+ T lymphocytes count was significantly lower in individuals with the IL-10-1082 GG genotype.
The TGF β -509TT genotype was associated with higher plasma viral load.
Conclusions.
The results suggest that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4+ T lymphocytes.
In addition, the genotype associated with high serum levels of TGF β may be associated with an increase in plasma viral load.
American Psychological Association (APA)
Bonfim Freitas, Felipe& Souza Lima, Sandra& Feitosa, Rosimar Neris Martins& Azevedo, Vânia Nakauth& Ishak, Marluísa de O. Guimarães& Ishak, Ricardo…[et al.]. 2015. Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060885
Modern Language Association (MLA)
Bonfim Freitas, Felipe…[et al.]. Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060885
American Medical Association (AMA)
Bonfim Freitas, Felipe& Souza Lima, Sandra& Feitosa, Rosimar Neris Martins& Azevedo, Vânia Nakauth& Ishak, Marluísa de O. Guimarães& Ishak, Ricardo…[et al.]. Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060885