Effects of Long-Term Statin Therapy in Coronary Artery Disease Patients with or without Chronic Kidney Disease
Joint Authors
Huang, Huiling
Zeng, Chunmei
Ma, Yuedong
Chen, Yili
Chen, Cong
Liu, Chen
Dong, Yugang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The effect of long-term statin therapy is essential for secondary prevention of adverse clinical outcomes of coronary artery disease (CAD) patients.
No study has compared the effects of long-term statin treatment in CAD patients with or without chronic kidney disease (CKD) and CKD only patients.
Methods.
We compared the effects of long-term statin therapy (average follow-up time 5.79 years) in terms of major adverse cardiovascular events (MACE), all-cause death, and cardiac death among 570 CAD patients with or without CKD and 147 CKD only patients.
Results.
The all-cause death and cardiac death of the patients with CAD and CKD (24.4% and 20.4%) doubled those of CAD only patients (10.7% and 9.1%) ( P < 0.001 ).
Long-term statin therapy dramatically reduced the rates of both MACE and all-cause death/cardiac death (by 20.5% and 28.6%/27.7%, resp.) in CAD and CKD patients.
CKD only patients had no significant adverse clinical outcomes and were not responsive to long-term statin therapy.
Conclusion.
Chinese CAD patients with CKD had dramatically high rates of adverse clinical outcomes; for them, long-term statin therapies were exceptionally effective in improving morbidity and mortality.
CKD patients who had no cardiovascular disease initially can prognose good clinical outcomes and do not require statin treatment.
American Psychological Association (APA)
Huang, Huiling& Zeng, Chunmei& Ma, Yuedong& Chen, Yili& Chen, Cong& Liu, Chen…[et al.]. 2015. Effects of Long-Term Statin Therapy in Coronary Artery Disease Patients with or without Chronic Kidney Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060887
Modern Language Association (MLA)
Huang, Huiling…[et al.]. Effects of Long-Term Statin Therapy in Coronary Artery Disease Patients with or without Chronic Kidney Disease. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060887
American Medical Association (AMA)
Huang, Huiling& Zeng, Chunmei& Ma, Yuedong& Chen, Yili& Chen, Cong& Liu, Chen…[et al.]. Effects of Long-Term Statin Therapy in Coronary Artery Disease Patients with or without Chronic Kidney Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060887