Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Latent autoimmune diabetes in adults (LADA) is the result of gene-environment interactions.
Histone acetylation regulates gene expression and maybe interpret how environmental factors modify LADA.
Hence, we studied the histone acetylation patterns in CD4+ T lymphocytes from LADA patients.
Methods.
Blood CD4+ T lymphocytes from 28 patients with LADA and 28 healthy controls were obtained to detect histone H3 acetylation and H4 acetylation.
The gene expression of histone acetyltransferases (P300 and CREBBP) and histone deacetylases (HDAC1, HDAC2, and HDAC7) was measured by real-time polymerase chain reaction (RT-PCR).
Results.
Compared to healthy controls, reduced global H3 acetylation was observed in LADA patients’ CD4+ T lymphocytes ( P < 0.05 ).
Global level of H4 acetylation was not statistically different.
Among LADA, CD4+ T lymphocytes H3 acetylation was associated with glycosylated hemoglobin (HbA1c) and GADA titer.
Compared to healthy controls, the expression of histone acetyltransferases CREBBP in LADA patients was downregulated, and the expression of histone deacetylases HDAC1 and HDAC7 was upregulated.
Conclusion.
A concerted downregulation of histone H3 acetylation was found in CD4+ T lymphocytes of LADA patients, and this might provide evidence of a novel epigenetic explanation for the pathogenesis of LADA and its complications.
American Psychological Association (APA)
Liu, Xi-yu& Xu, Jiang-feng. 2015. Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060895
Modern Language Association (MLA)
Liu, Xi-yu& Xu, Jiang-feng. Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060895
American Medical Association (AMA)
Liu, Xi-yu& Xu, Jiang-feng. Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060895