Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection
Joint Authors
Yoo, Tae
Park, Sang-Jae
Han, Sung-Sik
Kim, Seong Hoon
Lee, Seung Duk
Kim, Young-Kyu
Kim, Tae Hyun
Woo, Sang Myung
Lee, Woo Jin
Hong, Eun Kyung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
To investigate the clinical significance of the perioperative CA19-9 change for predicting survival in intrahepatic cholangiocarcinoma (ICC) patients treated with surgical resection.
Methods.
We retrospectively reviewed the data from 74 ICC patients treated with surgical resection between April 2001 and July 2010.
Perioperative CA19-9 (preoperative level, postoperative lowest level, and level at recurrence) levels were analyzed for patient distribution and survival.
Results.
Before surgery, there were 45 patients who had high preoperative CA19-9 levels (>37 U/mL) and 29 who had normal levels (≤37 U/mL).
Of 45 patients with high CA19-9 levels, 34 had normalized CA19-9 levels after resection and 11 had persistently high levels.
Of 34 patients with normalized CA19-9 levels, 18 showed recurrence.
Of 29 patients with normal preoperative levels, 15 showed recurrence.
Multivariate analysis presented that old age (hazard ratio [HR] = 3.881, p<0.01), persistently high postoperative CA19-9 level (HR = 4.41, p<0.001), perineural invasion (HR = 3.073, p=0.01), narrow resection margin (HR = 3.152, p=0.05), and lymph node metastasis (HR = 3.427, p=0.02) were significant independent risk factors for survival.
Conclusions.
Patients who have normalized CA19-9 levels postoperatively have longer survival outcomes.
Therefore, normalized postoperative CA19-9 may be a useful clinical marker for ICC survival.
American Psychological Association (APA)
Yoo, Tae& Park, Sang-Jae& Han, Sung-Sik& Kim, Seong Hoon& Lee, Seung Duk& Kim, Young-Kyu…[et al.]. 2015. Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060899
Modern Language Association (MLA)
Yoo, Tae…[et al.]. Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060899
American Medical Association (AMA)
Yoo, Tae& Park, Sang-Jae& Han, Sung-Sik& Kim, Seong Hoon& Lee, Seung Duk& Kim, Young-Kyu…[et al.]. Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060899