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Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer
Joint Authors
Grossi, Francesco
Dal Bello, Maria Giovanna
Salvi, Sandra
Puzone, Roberto
Pfeffer, Ulrich
Fontana, Vincenzo
Alama, Angela
Rijavec, Erika
Barletta, Giulia
Genova, Carlo
Sini, Claudio
Ratto, Giovanni Battista
Taviani, Mario
Truini, Mauro
Merlo, Domenico Franco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis.
To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we consecutively collected 82 tumour tissues from radically resected NSCLC patients.
The following biomarkers were investigated using IHC and qRT-PCR: excision repair cross-complementation group 1 (ERCC1), breast cancer 1 (BRCA1), ribonucleotide reductase subunits M1 and M2 (RRM1 and RRM2), subunit p53R2, thymidylate synthase (TS), and class III beta-tubulin (TUBB3).
Gene expression levels were also validated in an available NSCLC microarray dataset.
Multivariate analysis identified the protein overexpression of RRM2 and TS as independent prognostic factors of shorter overall survival (OS).
Kaplan-Meier analysis showed a trend in shorter OS for patients with RRM2, TS, and ERCC1, BRCA1 overexpressed tumours.
For all of the biomarkers except TUBB3, the OS trends relative to the gene expression levels were in agreement with those relative to the protein expression levels.
The NSCLC microarray dataset showed RRM2 and TS as biomarkers significantly associated with OS.
This study suggests that high expression levels of RRM2 and TS might be negative prognostic factors for resected NSCLC patients.
American Psychological Association (APA)
Grossi, Francesco& Dal Bello, Maria Giovanna& Salvi, Sandra& Puzone, Roberto& Pfeffer, Ulrich& Fontana, Vincenzo…[et al.]. 2015. Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1060901
Modern Language Association (MLA)
Grossi, Francesco…[et al.]. Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer. Disease Markers No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1060901
American Medical Association (AMA)
Grossi, Francesco& Dal Bello, Maria Giovanna& Salvi, Sandra& Puzone, Roberto& Pfeffer, Ulrich& Fontana, Vincenzo…[et al.]. Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1060901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060901