The Expression of NotchNotch Ligand, IL-35, IL-17, and Th17Treg in Preeclampsia
Joint Authors
Cao, Weiping
Wang, Xinzhi
Chen, Tinmei
Zhu, Huaying
Xu, Wenlin
Zhao, Songlan
Cheng, Xiaoqing
Xia, Liangping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to examine the interaction of Notch/Notch ligand with Th17/Treg, cytokines IL-35 and IL-17 in cases of preeclampsia (PE).
Methods.
Peripheral blood was obtained from 42 PE patients and 22 health pregnant women.
The mRNA expressions of Notch/Notch ligand, Treg transcription factor FoxP3 and Th17 transcription factor RORγt, EBI3 and P35 (IL-35 two subunits), and IL-17 were determined by qPCR.
The serum levels of IL-17 and IL-35 were measured by ELISA.
Results.
It was observed that the expressions of Foxp3, EBI3, and P35 in PE patients were lower compared with normal pregnancy, whereas the RORγt expression was significantly increased.
The results also demonstrated that PE patients exhibited decreased levels of Treg-related cytokine IL-35, whereas IL-17 was significantly increased.
PE patients expressed higher levels of Notch receptor (1–4) and Notch ligand of DLL4, whereas Notch ligand of Jagged-1, -2 was much lower.
Furthermore, the levels of FoxP3 T cells correlated positively with Jagged-2.
In addition, there were positive correlations between the mRNA level of IL-17 and DLL4.
Conclusion.
Our results indicated that maternal immunological changes may reverse maternal tolerance in PE, and this phenomenon may due to the Th17/Treg imbalance affected by Notch/Notch ligand.
American Psychological Association (APA)
Cao, Weiping& Wang, Xinzhi& Chen, Tinmei& Zhu, Huaying& Xu, Wenlin& Zhao, Songlan…[et al.]. 2015. The Expression of NotchNotch Ligand, IL-35, IL-17, and Th17Treg in Preeclampsia. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060904
Modern Language Association (MLA)
Cao, Weiping…[et al.]. The Expression of NotchNotch Ligand, IL-35, IL-17, and Th17Treg in Preeclampsia. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060904
American Medical Association (AMA)
Cao, Weiping& Wang, Xinzhi& Chen, Tinmei& Zhu, Huaying& Xu, Wenlin& Zhao, Songlan…[et al.]. The Expression of NotchNotch Ligand, IL-35, IL-17, and Th17Treg in Preeclampsia. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060904