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Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma
Joint Authors
Dodič-Fikfak, Metoda
Kovac, Viljem
Goričar, Katja
Franko, Alenka
Dolžan, Vita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Survivin is an inhibitor of apoptosis protein involved in the regulation of cell proliferation that could be used as a marker for cancer diagnosis or prognosis.
Our aim was to evaluate whether serum survivin levels influence the outcome of cisplatin-based chemotherapy in patients with malignant mesothelioma (MM).
Methods.
Serum survivin levels were determined using human survivin enzyme-linked immunosorbent assay in 78 MM patients before chemotherapy, after chemotherapy, and at disease progression.
The influence on tumor response and survival was evaluated using nonparametric tests and Cox regression.
Results.
A median serum survivin level at diagnosis was 4.1 (0–217.5) pg/mL.
Patients with a progressive disease had significantly higher survivin levels before chemotherapy (p = 0.041).
A median serum survivin level after chemotherapy was 73.1 (0–346.2) pg/mL.
If survivin levels increased after chemotherapy, patients had, conversely, better response (p = 0.001, OR = 5.40, 95% CI = 1.98–14.72).
Unexpectedly, patients with increased survivin levels after chemotherapy also had longer progression-free (p < 0.001, HR = 0.33, 95% CI = 0.20–0.57) and overall survival (p = 0.001, HR = 0.29, 95% CI = 0.14–0.58).
Conclusions.
These results suggest that serum survivin levels before and during chemotherapy could serve as a biomarker predicting MM treatment response.
American Psychological Association (APA)
Goričar, Katja& Kovac, Viljem& Franko, Alenka& Dodič-Fikfak, Metoda& Dolžan, Vita. 2015. Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060905
Modern Language Association (MLA)
Goričar, Katja…[et al.]. Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060905
American Medical Association (AMA)
Goričar, Katja& Kovac, Viljem& Franko, Alenka& Dodič-Fikfak, Metoda& Dolžan, Vita. Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060905