Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour
Joint Authors
Xue, Tong-min
Tao, Li-de
Zhang, Miao
Zhang, Jie
Liu, Xia
Chen, Guo-feng
Zhu, Yi-jia
Zhang, Pei-Jian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
miRNA-20b has been shown to be aberrantly expressed in several tumor types.
However, the clinical significance of miRNA-20b in the prognosis of patients with hepatocellular carcinoma (HCC) is poorly understood, and the exact role of miRNA-20b in HCC remains unclear.
The aim of the present study was to investigate the association of the expression of miR-20b with clinicopathological characteristics and overall survival of HCC patients analyzed by Kaplan-Meier analysis and Cox proportional hazards regression models.
Meanwhile, the HIF-1α and VEGF targets of miR-20b have been confirmed.
We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia.
This mechanism would help the tumor cells adapt to the different environments thus promoting the tumor invasion and development.
The whole study suggests that miR-20b, HIF-1α, and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma.
American Psychological Association (APA)
Xue, Tong-min& Tao, Li-de& Zhang, Miao& Zhang, Jie& Liu, Xia& Chen, Guo-feng…[et al.]. 2015. Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060907
Modern Language Association (MLA)
Xue, Tong-min…[et al.]. Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060907
American Medical Association (AMA)
Xue, Tong-min& Tao, Li-de& Zhang, Miao& Zhang, Jie& Liu, Xia& Chen, Guo-feng…[et al.]. Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060907