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MicroRNA-155 Hallmarks Promising Accuracy for the Diagnosis of Various Carcinomas: Results from a Meta-Analysis
Joint Authors
Wu, Chuancheng
Liu, Qiuyan
Liu, Baoying
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Recent studies have shown that microRNAs (miRNAs) have diagnostic values in various cancers.
This meta-analysis seeks to summarize the global diagnostic role of miR-155 in patients with a variety of carcinomas.
Methods.
Eligible studies were retrieved by searching the online databases, and the bivariate meta-analysis model was employed to generate the summary receiver operator characteristic (SROC) curve.
Results.
A total of 17 studies dealing with various carcinomas were finally included.
The results showed that single miR-155 testing allowed for the discrimination between cancer patients and healthy donors with a sensitivity of 0.82 (95% CI: 0.73–0.88) and specificity of 0.77 (95% CI: 0.70–0.83), corresponding to an area under curve (AUC) of 0.85, while a panel comprising expressions of miR-155 yielded a sensitivity of 0.76 (95% CI: 0.68–0.82) and specificity of 0.82 (95% CI: 0.77–0.86) in diagnosing cancers.
The subgroup analysis displayed that serum miR-155 test harvested higher accuracy than plasma-based assay (the AUC, sensitivity, and specificity were, resp., 0.87 versus 0.73, 0.78 versus 0.74, and 0.77 versus 0.70).
Conclusions.
Our data suggest that single miR-155 profiling has a potential to be used as a screening test for various carcinomas, and parallel testing of miR-155 confers an improved specificity compared to single miR-155 analysis.
American Psychological Association (APA)
Wu, Chuancheng& Liu, Qiuyan& Liu, Baoying. 2015. MicroRNA-155 Hallmarks Promising Accuracy for the Diagnosis of Various Carcinomas: Results from a Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060909
Modern Language Association (MLA)
Wu, Chuancheng…[et al.]. MicroRNA-155 Hallmarks Promising Accuracy for the Diagnosis of Various Carcinomas: Results from a Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1060909
American Medical Association (AMA)
Wu, Chuancheng& Liu, Qiuyan& Liu, Baoying. MicroRNA-155 Hallmarks Promising Accuracy for the Diagnosis of Various Carcinomas: Results from a Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060909