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Perspective Biological Markers for Autism Spectrum Disorders: Advantages of the Use of Receiver Operating Characteristic Curves in Evaluating Marker Sensitivity and Specificity
Joint Authors
Abruzzo, Provvidenza Maria
Marini, Marina
Bolotta, Alessandra
Ghezzo, Alessandro
Ferreri, Carla
Minguzzi, Renato
Vignini, Arianna
Visconti, Paola
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Autism Spectrum Disorders (ASD) are a heterogeneous group of neurodevelopmental disorders.
Recognized causes of ASD include genetic factors, metabolic diseases, toxic and environmental factors, and a combination of these.
Available tests fail to recognize genetic abnormalities in about 70% of ASD children, where diagnosis is solely based on behavioral signs and symptoms, which are difficult to evaluate in very young children.
Although it is advisable that specific psychotherapeutic and pedagogic interventions are initiated as early as possible, early diagnosis is hampered by the lack of nongenetic specific biological markers.
In the past ten years, the scientific literature has reported dozens of neurophysiological and biochemical alterations in ASD children; however no real biomarker has emerged.
Such literature is here reviewed in the light of Receiver Operating Characteristic (ROC) analysis, a very valuable statistical tool, which evaluates the sensitivity and the specificity of biomarkers to be used in diagnostic decision making.
We also apply ROC analysis to some of our previously published data and discuss the increased diagnostic value of combining more variables in one ROC curve analysis.
We also discuss the use of biomarkers as a tool for advancing our understanding of nonsyndromic ASD.
American Psychological Association (APA)
Abruzzo, Provvidenza Maria& Ghezzo, Alessandro& Bolotta, Alessandra& Ferreri, Carla& Minguzzi, Renato& Vignini, Arianna…[et al.]. 2015. Perspective Biological Markers for Autism Spectrum Disorders: Advantages of the Use of Receiver Operating Characteristic Curves in Evaluating Marker Sensitivity and Specificity. Disease Markers،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1060910
Modern Language Association (MLA)
Abruzzo, Provvidenza Maria…[et al.]. Perspective Biological Markers for Autism Spectrum Disorders: Advantages of the Use of Receiver Operating Characteristic Curves in Evaluating Marker Sensitivity and Specificity. Disease Markers No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1060910
American Medical Association (AMA)
Abruzzo, Provvidenza Maria& Ghezzo, Alessandro& Bolotta, Alessandra& Ferreri, Carla& Minguzzi, Renato& Vignini, Arianna…[et al.]. Perspective Biological Markers for Autism Spectrum Disorders: Advantages of the Use of Receiver Operating Characteristic Curves in Evaluating Marker Sensitivity and Specificity. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1060910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060910